Mechanisms of resistance to irreversible epidermal growth factor receptor tyrosine kinase inhibitors and therapeutic strategies in non-small cell lung cancer

Epidermal growth factor receptor (EGFR) T790M mutation is the most frequent mechanism which accounts for about 60% of acquired resistance to first-generation EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) patients harboring EGFR activating mutations. Irreversible EGFR-T...

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Vydáno v:Oncotarget
Hlavní autoři: Xu, Jing, Wang, Jinghui, Zhang, Shucai
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685774/
https://ncbi.nlm.nih.gov/pubmed/29163853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21164
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