Impaired GABA(B)-mediated presynaptic inhibition increases excitatory strength and alters short-term plasticity in synapsin knockout mice

Synapsins are a family of synaptic vesicle phosphoproteins regulating synaptic transmission and plasticity. SYN1/2 genes are major epilepsy susceptibility genes in humans. Consistently, synapsin I/II/III triple knockout (TKO) mice are epileptic and exhibit severe impairments in phasic and tonic GABA...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Valente, Pierluigi, Farisello, Pasqualina, Valtorta, Flavia, Baldelli, Pietro, Benfenati, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685732/
https://ncbi.nlm.nih.gov/pubmed/29163811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21405
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