Structural and kinetic considerations on the catalysis of deoxyarbutin by tyrosinase

Deoxyarbutin, a potent inhibitor of tyrosinase, could act as substrate of the enzyme. Oxytyrosinase is able to hydroxylate deoxyarbutin and finishes the catalytic cycle by oxidizing the formed o-diphenol to quinone, while the enzyme becomes deoxytyrosinase, which evolves to oxytyrosinase in the pres...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Garcia-Jimenez, Antonio, Teruel-Puche, Jose Antonio, Garcia-Ruiz, Pedro Antonio, Saura-Sanmartin, Adrian, Berna, Jose, Garcia-Canovas, Francisco, Rodriguez-Lopez, José Neptuno
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685642/
https://ncbi.nlm.nih.gov/pubmed/29136639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187845
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