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Lipoprotein(a)-Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis

The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets categorized pathologically from both ATX–apolipoprotein B and ATX–apo...

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Bibliographische Detailangaben
Veröffentlicht in:JACC Basic Transl Sci
Hauptverfasser: Torzewski, Michael, Ravandi, Amir, Yeang, Calvin, Edel, Andrea, Bhindi, Rahul, Kath, Stefan, Twardowski, Laura, Schmid, Jens, Yang, Xiaohong, Franke, Ulrich F.W., Witztum, Joseph L., Tsimikas, Sotirios
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685511/
https://ncbi.nlm.nih.gov/pubmed/29147686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2017.02.004
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