Lipoprotein(a)-Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis

The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets categorized pathologically from both ATX–apolipoprotein B and ATX–apo...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Torzewski, Michael, Ravandi, Amir, Yeang, Calvin, Edel, Andrea, Bhindi, Rahul, Kath, Stefan, Twardowski, Laura, Schmid, Jens, Yang, Xiaohong, Franke, Ulrich F.W., Witztum, Joseph L., Tsimikas, Sotirios
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
CLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685511/
https://ncbi.nlm.nih.gov/pubmed/29147686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2017.02.004
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