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Metformin extends C. elegans lifespan through lysosomal pathway
Metformin, a widely used first-line drug for treatment of type 2 diabetes (T2D), has been shown to extend lifespan and delay the onset of age-related diseases. However, its primary locus of action remains unclear. Using a pure in vitro reconstitution system, we demonstrate that metformin acts throug...
Gorde:
| Argitaratua izan da: | eLife |
|---|---|
| Egile Nagusiak: | , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
eLife Sciences Publications, Ltd
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5685485/ https://ncbi.nlm.nih.gov/pubmed/29027899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31268 |
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