Autoimmune response to AGE modified human DNA: Implications in type 1 diabetes mellitus()

AIMS: Non-enzymatic glycation of DNA both in vivo and in vitro results in generation of free radicals, known as glycoxidation. Glycoxidation leads to structural perturbation of DNA resulting in generation of neo-antigenic epitopes having implication in autoimmune disorders like diabetes mellitus. In...

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Dades bibliogràfiques
Publicat a:J Clin Transl Endocrinol
Autors principals: Ahmad, Saheem, Uddin, Moin, Habib, Safia, Shahab, Uzma, Alam, Khursheed, Ali, Asif
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685016/
https://ncbi.nlm.nih.gov/pubmed/29159085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcte.2014.05.002
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