Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes

We compared whole exome sequencing (WES, n = 176 patients) and whole genome sequencing (WGS, n = 68) and clinical genotyping (DMET array-based approach) for interrogating 13 genes with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. We focused on 127 CPIC important variants: 1...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Yang, W, Wu, G, Broeckel, U, Smith, CA, Turner, V, Haidar, CE, Wang, S, Carter, R, Karol, SE, Neale, G, Crews, KR, Yang, JJ, Mullighan, CG, Downing, JR, Evans, WE, Relling, MV
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684873/
https://ncbi.nlm.nih.gov/pubmed/27311679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.411
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