Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

The influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on thiopurine-induced adverse events has not been investigated in the context of combination chemotherapy for acute lymphoblastic leukemia (ALL). This study investigated the effects of a common ITPA variant allele (...

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Detalhes bibliográficos
Main Authors: Stocco, G, Cheok, MH, Crews, KR, Dervieux, T, French, D, Pei, D, Yang, W, Cheng, C, Pui, C-H, Relling, MV, Evans, WE
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762405/
https://ncbi.nlm.nih.gov/pubmed/18685564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2008.154
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