An environmental pollutant, 9,10‐phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665

Transient receptor potential ankyrin 1 (TRPA1) is activated by noxious cold, mechanical stimulation, and irritant chemicals. In our recent study, 9, 10‐phenanthrenequinone (9,10‐PQ) is the most potent irritant for activation of NRF2 among 1395 cigarette smoke components and it may be, therefore, imp...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Muraki, Katsuhiko, Sekine, Takashi, Ando, Yuna, Suzuki, Hiroka, Hatano, Noriyuki, Hirata, Tadashi, Muraki, Yukiko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684862/
https://ncbi.nlm.nih.gov/pubmed/28805980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.342
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