An environmental pollutant, 9,10‐phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665

Transient receptor potential ankyrin 1 (TRPA1) is activated by noxious cold, mechanical stimulation, and irritant chemicals. In our recent study, 9, 10‐phenanthrenequinone (9,10‐PQ) is the most potent irritant for activation of NRF2 among 1395 cigarette smoke components and it may be, therefore, imp...

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Dades bibliogràfiques
Publicat a:Pharmacol Res Perspect
Autors principals: Muraki, Katsuhiko, Sekine, Takashi, Ando, Yuna, Suzuki, Hiroka, Hatano, Noriyuki, Hirata, Tadashi, Muraki, Yukiko
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684862/
https://ncbi.nlm.nih.gov/pubmed/28805980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.342
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