IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8(+) T Cell Responses in Acute Simian Immunodeficiency Virus Infection

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4(+) T cells occur regardless of the portal of entr...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Méndez-Lagares, Gema, Lu, Ding, Merriam, David, Baker, Christopher A., Villinger, François, Van Rompay, Koen K. A., McCune, Joseph M., Hartigan-O'Connor, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684667/
https://ncbi.nlm.nih.gov/pubmed/29140110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2017.0160
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