Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

OBJECTIVE: The aim of the present study was to improve bioavailability of an important antiretroviral drug, Darunavir (DRV), which has low water solubility and poor intestinal absorption through solid dispersion (SD) approach incorporating polymer with P-glycoprotein inhibitory potential. METHODS: A...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Rehman, Saleha, Nabi, Bushra, Fazil, Mohammad, Khan, Saba, Bari, Naimat Kalim, Singh, Romi, Ahmad, Shavej, Kumar, Varinder, Baboota, Sanjula, Ali, Javed
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684613/
https://ncbi.nlm.nih.gov/pubmed/29226149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8274927
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