Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma

Inhibition of the interaction between p53 and HDM2 is an effective therapeutic strategy in cancers that harbor a wild-type p53 protein such as retinoblastoma (RB). Nanoparticle-based delivery of therapeutic molecules has been shown to be advantageous in localized delivery, including to the eye, by o...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Kalmodia, Sushma, Parameswaran, Sowmya, Ganapathy, Kalaivani, Yang, Wenrong, Barrow, Colin J., Kanwar, Jagat R., Roy, Kislay, Vasudevan, Madavan, Kulkarni, Kirti, Elchuri, Sailaja V., Krishnakumar, Subramanian
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684491/
https://ncbi.nlm.nih.gov/pubmed/29246314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.10.012
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