O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress

SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet...

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Vydáno v:Nat Commun
Hlavní autoři: Han, Cuifang, Gu, Yuchao, Shan, Hui, Mi, Wenyi, Sun, Jiahui, Shi, Minghui, Zhang, Xinling, Lu, Xinzhi, Han, Feng, Gong, Qianhong, Yu, Wengong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684413/
https://ncbi.nlm.nih.gov/pubmed/29133780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01654-6
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