Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

Nanomedicines that co-deliver DNA, RNA, and peptide therapeutics are highly desirable yet remain underdeveloped for cancer theranostics. Herein, we report self-assembled intertwining DNA-RNA nanocapsules (iDR-NCs) that efficiently delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants...

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Vydáno v:Nat Commun
Hlavní autoři: Zhu, Guizhi, Mei, Lei, Vishwasrao, Harshad D., Jacobson, Orit, Wang, Zhantong, Liu, Yijing, Yung, Bryant C., Fu, Xiao, Jin, Albert, Niu, Gang, Wang, Qin, Zhang, Fuwu, Shroff, Hari, Chen, Xiaoyuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684198/
https://ncbi.nlm.nih.gov/pubmed/29133898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01386-7
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