Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue

Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose triglyceride lipase (ATGL) is considered a key step in NST. Accordingly, the severe cold intolerance of global ATGL knockout (AKO...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Schreiber, Renate, Diwoky, Clemens, Schoiswohl, Gabriele, Feiler, Ursula, Wongsiriroj, Nuttaporn, Abdellatif, Mahmoud, Kolb, Dagmar, Hoeks, Joris, Kershaw, Erin E., Sedej, Simon, Schrauwen, Patrick, Haemmerle, Guenter, Zechner, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683855/
https://ncbi.nlm.nih.gov/pubmed/28988821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.09.004
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