Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts

Fibroblasts differ in a variety of phenotypic features, including the expression of Thy-1 a glycophosphatidylinositol-linked glycoprotein. Fibroblasts in idiopathic pulmonary fibrosis (IPF) are Thy-1-negative, while most fibroblasts from normal lungs are Thy-1-positive. However, the functional conse...

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Pubblicato in:Lab Invest
Autori principali: Ramírez, Gustavo, Hagood, James S., Sanders, Yan, Ramírez, Remedios, Becerril, Carina, Segura, Lourdes, Barrera, Lourdes, Selman, Moisés, Pardo, Annie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683845/
https://ncbi.nlm.nih.gov/pubmed/21577212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2011.80
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