Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS

BACKGROUND: Melanoma differentiation associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) selectively sense cytoplasmic viral RNA to induce an antiviral immune response. Infectious bronchitis virus (IBV) is one of the most important infectious agents in chickens, and in chicken cells,...

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Pubblicato in:BMC Vet Res
Autori principali: Yu, Liping, Zhang, Xiaorong, Wu, Tianqi, Su, Jin, Wang, Yuyang, Wang, Yuexin, Ruan, Baoyang, Niu, Xiaosai, Wu, Yantao
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683607/
https://ncbi.nlm.nih.gov/pubmed/29132350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12917-017-1253-7
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