Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex

Prokaryotic cells possess CRISPR-mediated adaptive immune systems that protect them from foreign genetic elements, such as invading viruses. A central element of this immune system is an RNA-guided surveillance complex capable of targeting non-self DNA or RNA for degradation in a sequence- and site-...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Guo, Tai Wei, Bartesaghi, Alberto, Yang, Hui, Falconieri, Veronica, Rao, Prashant, Merk, Alan, Eng, Edward T., Raczkowski, Ashleigh M., Fox, Tara, Earl, Lesley A., Patel, Dinshaw, Subramaniam, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683424/
https://ncbi.nlm.nih.gov/pubmed/28985564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.006
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