Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury

Therapeutics used to treat central nervous system (CNS) injury were designed to repair neurites and inhibit cell apoptosis. Previous studies have shown that neuron-derived FGF10 exerts potential neuroprotective effects after cerebral ischemia injury. However, little is known about the role of endoge...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Chen, Jian, Wang, Zhouguang, Zheng, ZengMing, Chen, Yu, Khor, Sinan, Shi, KeSi, He, ZiLi, Wang, Qingqing, Zhao, Yingzheng, Zhang, Hongyu, Li, Xiaokun, Li, Jiawei, Yin, Jiayu, Wang, Xiangyang, Xiao, Jian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682656/
https://ncbi.nlm.nih.gov/pubmed/28981091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.490
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