IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression

Plasma cell differentiation is a tightly regulated process that requires appropriate T cell helps to reach the induction threshold. To further understand mechanisms by which T cell inputs regulate B cell fate decision, we investigate the minimal IL-2 stimulation for triggering human plasma cell diff...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hipp, Nicolas, Symington, Hannah, Pastoret, Cédric, Caron, Gersende, Monvoisin, Céline, Tarte, Karin, Fest, Thierry, Delaloy, Céline
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682283/
https://ncbi.nlm.nih.gov/pubmed/29129929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01475-7
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