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Antivitamin B(12) Inhibition of Human B(12)-Processing Enzyme CblC - Crystal Structure of Abortive Ternary Complex with Cosubstrate Glutathione
Antivitamins B(12) have a growing biomedical impact as robust B(12)-dummies. Here, the potential antivitamin B(12) 2,4-difluorophenyl-ethynyl-cobalamin (F2PhEtyCbl) was prepared and its 3D-structure was studied in solution and in the crystal. Chemically inert F2PhEtyCbl resisted thermolysis of its (...
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| Wydane w: | Angew Chem Int Ed Engl |
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| Główni autorzy: | , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5681751/ https://ncbi.nlm.nih.gov/pubmed/28544088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201701583 |
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