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Antivitamin B(12) Inhibition of Human B(12)-Processing Enzyme CblC - Crystal Structure of Abortive Ternary Complex with Cosubstrate Glutathione

Antivitamins B(12) have a growing biomedical impact as robust B(12)-dummies. Here, the potential antivitamin B(12) 2,4-difluorophenyl-ethynyl-cobalamin (F2PhEtyCbl) was prepared and its 3D-structure was studied in solution and in the crystal. Chemically inert F2PhEtyCbl resisted thermolysis of its (...

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Библиографические подробности
Опубликовано в: :Angew Chem Int Ed Engl
Главные авторы: Ruetz, Markus, Shanmuganathan, Aranganathan, Gherasim, Carmen, Karasik, Agnes, Salchner, Robert, Kieninger, Christoph, Wurst, Klaus, Banerjee, Ruma, Koutmos, Markos, Kräutler, Bernhard
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681751/
https://ncbi.nlm.nih.gov/pubmed/28544088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201701583
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