Hyperglycemia Promotes TMPRSS2-ERG Gene Fusion in Prostate Cancer Cells via Upregulating Insulin-Like Growth Factor-Binding Protein-2

BACKGROUND: Epidemiologic evidence shows that obesity is associated with a greater risk of aggressive prostate cancer (PCa) and PCa-specific mortality and this is observed mainly in men with the TMPRSS2-ERG gene fusion. Obesity is often associated with comorbid conditions such as type 2 diabetes and...

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Udgivet i:Front Endocrinol (Lausanne)
Main Authors: Holly, Jeff M. P., Broadhurst, Jessica, Mansor, Rehanna, Bahl, Amit, Perks, Claire M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Endocrinology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681733/
https://ncbi.nlm.nih.gov/pubmed/29163372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2017.00305
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