Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

OBJECTIVE: Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin sensitivity in mice. However, while ChREBP is most highly e...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Jois, Tara, Chen, Weiyi, Howard, Victor, Harvey, Rebecca, Youngs, Kristina, Thalmann, Claudia, Saha, Pradip, Chan, Lawrence, Cowley, Michael A., Sleeman, Mark W.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681238/
https://ncbi.nlm.nih.gov/pubmed/29107286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.07.006
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