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Effect of cell cycle duration on somatic evolutionary dynamics

Cellular checkpoints prevent damage and mutation accumulation in tissue cells. DNA repair is one mechanism that can be triggered by checkpoints and involves temporary cell cycle arrest and thus delayed reproduction. Repair‐deficient cells avoid this delay, which has been argued to lead to a selectiv...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Evol Appl
Main Authors: Wodarz, Dominik, Goel, Ajay, Komarova, Natalia L.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680637/
https://ncbi.nlm.nih.gov/pubmed/29151865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/eva.12518
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