Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death

BACKGROUND: Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1α) levels and glycolysis in tumour cells are associated with an increased risk of mortality, cancer progression, and resistance to therapy. However, the...

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Pubblicato in:Br J Cancer
Autori principali: Li, Sainan, Li, Jingjing, Dai, Weiqi, Zhang, Qinghui, Feng, Jiao, Wu, Liwei, Liu, Tong, Yu, Qiang, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Chen, Kan, Xia, Yujing, Lu, Jie, Zhou, Yingqun, Fan, Xiaoming, Mo, Wenhui, Xu, Ling, Guo, Chuanyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680469/
https://ncbi.nlm.nih.gov/pubmed/28926527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.323
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