Camptothecin suppresses NRF2–ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs

BACKGROUND: Resistance to chemotherapy is a major obstacle in the treatment of human hepatocellular carcinoma (HCC). Despite playing an important role in chemoprevention, nuclear factor erythroid 2-related factor 2 (NRF2) also contributes to chemo- and radio-resistance. The current study focusses on...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Chen, Feng, Wang, Huihui, Zhu, Jiayu, Zhao, Rui, Xue, Peng, Zhang, Qiang, Bud Nelson, M, Qu, Weidong, Feng, Bo, Pi, Jingbo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680465/
https://ncbi.nlm.nih.gov/pubmed/28910823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.317
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