Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

Cerebrovascular changes occur in Alzheimer’s disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus...

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Udgivet i:Nat Commun
Main Authors: Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Braun, Gary B., Mölder, Tarmo, Toome, Kadri, Ambasudhan, Rajesh, Teesalu, Tambet, Lipton, Stuart A., Ruoslahti, Erkki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680235/
https://ncbi.nlm.nih.gov/pubmed/29123083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01096-0
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