Prevalence and detection of low-allele-fraction variants in clinical cancer samples

Accurate detection of genomic alterations using high-throughput sequencing is an essential component of precision cancer medicine. We characterize the variant allele fractions (VAFs) of somatic single nucleotide variants and indels across 5095 clinical samples profiled using a custom panel, CancerSC...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Shin, Hyun-Tae, Choi, Yoon-La, Yun, Jae Won, Kim, Nayoung K. D., Kim, Sook-Young, Jeon, Hyo Jeong, Nam, Jae-Yong, Lee, Chung, Ryu, Daeun, Kim, Sang Cheol, Park, Kyunghee, Lee, Eunjin, Bae, Joon Seol, Son, Dae Soon, Joung, Je-Gun, Lee, Jeeyun, Kim, Seung Tae, Ahn, Myung-Ju, Lee, Se-Hoon, Ahn, Jin Seok, Lee, Woo Yong, Oh, Bo Young, Park, Yeon Hee, Lee, Jeong Eon, Lee, Kwang Hyuk, Kim, Hee Cheol, Kim, Kyoung-Mee, Im, Young-Hyuck, Park, Keunchil, Park, Peter J., Park, Woong-Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680209/
https://ncbi.nlm.nih.gov/pubmed/29123093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01470-y
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