Clinical implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes

Breast cancer (BC) has been genetically profiled through large-scale genome analyses. However, the role and clinical implications of genetic alterations in metastatic BC (MBC) have not been evaluated. Therefore, we conducted whole-exome sequencing (WES) and RNA-Seq of 37 MBC samples and targeted dee...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kim, Ji-Yeon, Lee, Eunjin, Park, Kyunghee, Park, Woong-Yang, Jung, Hae Hyun, Ahn, Jin Seok, Im, Young-Hyuck, Park, Yeon Hee
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438625/
https://ncbi.nlm.nih.gov/pubmed/28427202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15881
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