Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

The SMOOTHENED inhibitor vismodegib is FDA approved for advanced basal cell carcinoma (BCC), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patients. Clinical experience with BCC patients shows that continuous exposure to vismodegib is necessary to preven...

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Publicado en:Oncogene
Autores principales: Rodriguez-Blanco, J, Pednekar, L, Penas, C, Li, B, Martin, V, Long, J, Lee, E, Weiss, WA, Rodriguez, C, Mehrdad, N, Nguyen, DM, Ayad, NG, Rai, P, Capobianco, AJ, Robbins, DJ
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680121/
https://ncbi.nlm.nih.gov/pubmed/28714964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.232
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