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Loss of Kdm5c causes spurious transcription and prevents the fine-tuning of activity-regulated enhancers in neurons

During development, chromatin-modifying enzymes regulate both the timely establishment of cell type-specific gene programs and the coordinated repression of alternative cell fates. To dissect the role of one such enzyme - the intellectual disability-linked lysine demethylase 5C gene (Kdm5c) – in the...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Scandaglia, Marilyn, Lopez-Atalaya, Jose P., Medrano-Fernandez, Alejandro, Lopez-Cascales, Maria T., del Blanco, Beatriz, Lipinski, Michal, Benito, Eva, Olivares, Roman, Iwase, Shigeki, Shi, Yang, Barco, Angel
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679733/
https://ncbi.nlm.nih.gov/pubmed/28978483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.014
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