KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain

The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain unclear. Here, we show that the combined elimination of both proteins in forebrain excitatory neurons of adult mice r...

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Vydáno v:Nat Commun
Hlavní autoři: Lipinski, Michal, Muñoz-Viana, Rafael, del Blanco, Beatriz, Marquez-Galera, Angel, Medrano-Relinque, Juan, Caramés, José M., Szczepankiewicz, Andrzej A., Fernandez-Albert, Jordi, Navarrón, Carmen M., Olivares, Roman, Wilczyński, Grzegorz M., Canals, Santiago, Lopez-Atalaya, Jose P., Barco, Angel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244750/
https://ncbi.nlm.nih.gov/pubmed/32444594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16246-0
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