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Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

Generation of the lipid messenger phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is crucial for development, cell growth and survival, and motility, and it becomes dysfunctional in many diseases including cancers. Here we reveal a mechanism for PtdIns(3,4,5)P(3) generation by scaffolde...

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Bibliografiske detaljer
Udgivet i:Nat Cell Biol
Main Authors: Choi, Suyong, Hedman, Andrew C., Sayedyahossein, Samar, Thapa, Narendra, Sacks, David B., Anderson, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679705/
https://ncbi.nlm.nih.gov/pubmed/27870828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3441
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