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Plasmid DNA Launches Live-Attenuated Japanese Encephalitis Virus and Elicits Virus-Neutralizing Antibodies in BALB/c Mice

We describe novel plasmid DNA that encodes the full-length Japanese encephalitis virus (JEV) genomic cDNA and launches live-attenuated JEV vaccine in vitro and in vivo. The synthetic cDNA based on the sequence of JEV SA14-14-2 live-attenuated virus was placed under transcriptional control of the cyt...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Nickols, Brian, Tretyakova, Irina, Tibbens, Alexander, Klyushnenkova, Elena, Pushko, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679062/
https://ncbi.nlm.nih.gov/pubmed/28938099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.09.005
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