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The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue

Chemokine CXCL12 gradients drive chemotaxis in a CXCR4-dependent mechanism and have been implicated in cancer metastasis. While CXCL12 gradients are typically studied in organized, defined environments, the tumor microenvironment is disorganized. In vivo, CXCL12 gradients depend on many factors: the...

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Podrobná bibliografie
Vydáno v:PLoS One
Hlavní autoři: Spinosa, Phillip C., Luker, Kathryn E., Luker, Gary D., Linderman, Jennifer J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678865/
https://ncbi.nlm.nih.gov/pubmed/29117251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187357
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