The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue

Chemokine CXCL12 gradients drive chemotaxis in a CXCR4-dependent mechanism and have been implicated in cancer metastasis. While CXCL12 gradients are typically studied in organized, defined environments, the tumor microenvironment is disorganized. In vivo, CXCL12 gradients depend on many factors: the...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Spinosa, Phillip C., Luker, Kathryn E., Luker, Gary D., Linderman, Jennifer J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678865/
https://ncbi.nlm.nih.gov/pubmed/29117251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187357
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