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The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue

Chemokine CXCL12 gradients drive chemotaxis in a CXCR4-dependent mechanism and have been implicated in cancer metastasis. While CXCL12 gradients are typically studied in organized, defined environments, the tumor microenvironment is disorganized. In vivo, CXCL12 gradients depend on many factors: the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Spinosa, Phillip C., Luker, Kathryn E., Luker, Gary D., Linderman, Jennifer J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678865/
https://ncbi.nlm.nih.gov/pubmed/29117251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187357
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