Co-targeting PI3K, mTOR, and IGF1R with small molecule inhibitors for treating undifferentiated pleomorphic sarcoma

Undifferentiated pleomorphic sarcomas (UPSs) are aggressive mesenchymal malignancies with no definitive cell of origin or specific recurrent genetic hallmarks. These tumors are largely chemoresistant; thus, identification of potential therapeutic targets is necessary to improve patient outcome. Prev...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: May, Caitlin D., Landers, Sharon M., Bolshakov, Svetlana, Ma, XiaoYan, Ingram, Davis R., Kivlin, Christine M., Watson, Kelsey L., Sannaa, Ghadah A. Al, Bhalla, Angela D., Wang, Wei-Lien, Lazar, Alexander J., Torres, Keila E.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678691/
https://ncbi.nlm.nih.gov/pubmed/29099264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1373230
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