RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

BACKGROUND: TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Furthermore, its RNA-binding domain...

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Publicado en:BMC Biol
Autores principales: Choudhury, Nila Roy, Heikel, Gregory, Trubitsyna, Maryia, Kubik, Peter, Nowak, Jakub Stanislaw, Webb, Shaun, Granneman, Sander, Spanos, Christos, Rappsilber, Juri, Castello, Alfredo, Michlewski, Gracjan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678581/
https://ncbi.nlm.nih.gov/pubmed/29117863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-017-0444-9
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