An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells

Erasure of DNA methylation and repressive chromatin marks in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs). Here, we used mouse embryonic stem cells (ESCs) to identify an endosiRNA-based mechanism involved in suppression of TE transcription. In ESC...

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Publicado no:Cell Stem Cell
Main Authors: Berrens, Rebecca V., Andrews, Simon, Spensberger, Dominik, Santos, Fátima, Dean, Wendy, Gould, Poppy, Sharif, Jafar, Olova, Nelly, Chandra, Tamir, Koseki, Haruhiko, von Meyenn, Ferdinand, Reik, Wolf
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678422/
https://ncbi.nlm.nih.gov/pubmed/29100015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.10.004
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