Suppression of the FA pathway combined with CHK1 inhibitor hypersensitize lung cancer cells to gemcitabine

The combination of platinum and gemcitabine is one of the standard regimens in the treatment of advanced lung squamous carcinoma (LSC). Resistance to gemcitabine is main barrier to the successful treatment of LSC. In this study, we showed that suppression of the Fanconi anemia (FA) pathway increased...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Dai, Chun-Hua, Wang, Yi, Chen, Ping, Jiang, Qian, Lan, Ting, Li, Mei-Yu, Su, Jin-Yu, Wu, Yan, Li, Jian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678185/
https://ncbi.nlm.nih.gov/pubmed/29118324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15172-4
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