Gemcitabine and Chk1 inhibitor AZD7762 synergistically suppress the growth of Lkb1-deficient lung adenocarcinoma

Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered m...

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Vydáno v:Cancer Res
Hlavní autoři: Liu, Yan, Li, Yuyang, Wang, Xiaoen, Liu, Feiyang, Gao, Peng, Quinn, Max M., Li, Fei, Merlino, Ashley A, Benes, Cyril, Liu, Qingsong, Gray, Nathanael, Wong, Kwok-kin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600859/
https://ncbi.nlm.nih.gov/pubmed/28754670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0567
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