Suppression of the FA pathway combined with CHK1 inhibitor hypersensitize lung cancer cells to gemcitabine

The combination of platinum and gemcitabine is one of the standard regimens in the treatment of advanced lung squamous carcinoma (LSC). Resistance to gemcitabine is main barrier to the successful treatment of LSC. In this study, we showed that suppression of the Fanconi anemia (FA) pathway increased...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Dai, Chun-Hua, Wang, Yi, Chen, Ping, Jiang, Qian, Lan, Ting, Li, Mei-Yu, Su, Jin-Yu, Wu, Yan, Li, Jian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678185/
https://ncbi.nlm.nih.gov/pubmed/29118324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15172-4
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