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The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis

The trafficking behavior of the lipid raft-dwelling US9 protein from Herpes Simplex Virus strikingly overlaps with that of the amyloid precursor protein (APP). Both US9 and APP processing machinery rely on their ability to shuttle between endosomes and plasma membranes, as well as on their lateral a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Brandimarti, Renato, Hill, Gordon S., Geiger, Jonathan D., Meucci, Olimpia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678071/
https://ncbi.nlm.nih.gov/pubmed/29118375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15128-8
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