Prostaglandin E1 protects hepatocytes against endoplasmic reticulum stress-induced apoptosis via protein kinase A-dependent induction of glucose-regulated protein 78 expression

AIM: To investigate the protective effect of prostaglandin E1 (PGE1) against endoplasmic reticulum (ER) stress-induced hepatocyte apoptosis, and to explore its underlying mechanisms. METHODS: Thapsigargin (TG) was used to induce ER stress in the human hepatic cell line L02 and hepatocarcinoma-derive...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Yang, Fang-Wan, Fu, Yu, Li, Ying, He, Yi-Huai, Mu, Mao-Yuan, Liu, Qi-Chuan, Long, Jun, Lin, Shi-De
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2017
Assuntos:
Basic Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677201/
https://ncbi.nlm.nih.gov/pubmed/29142472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i40.7253
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