Thalidomide Inhibits TGF-β1-induced Epithelial to Mesenchymal Transition in Alveolar Epithelial Cells via Smad-Dependent and Smad-Independent Signaling Pathways

Recent evidence indicates that the epithelial to mesenchymal transition (EMT) in primary alveolar cells (AECs) plays an important role in idiopathic pulmonary fibrosis (IPF). In vivo models have suggested that thalidomide (THL) has anti-fibrotic effects against pulmonary fibrosis, but the underlying...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhou, Xian-Long, Xu, Peng, Chen, Hai-Hua, Zhao, Yan, Shen, Jun, Jiang, Cheng, Jiang, Shan, Ni, Shao-Zhou, Xu, Bing, Li, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677010/
https://ncbi.nlm.nih.gov/pubmed/29116196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15239-2
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