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Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale

Although bacterial bioactive metabolites have been one of the most prolific sources of lead structures for the development of small-molecule therapeutics, very little is known about the environmental factors associated with changes in secondary metabolism across natural environments. Large-scale seq...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Lemetre, Christophe, Maniko, Jeffrey, Charlop-Powers, Zachary, Sparrow, Ben, Lowe, Andrew J., Brady, Sean F.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676913/
https://ncbi.nlm.nih.gov/pubmed/29078342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710262114
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