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Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters
Large-scale sequencing of prokaryotic (meta)genomic DNA suggests that most bacterial natural product gene clusters are not expressed under common laboratory culture conditions. Silent gene clusters represent a promising resource for natural product discovery and the development of a new generation o...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517240/ https://ncbi.nlm.nih.gov/pubmed/26150486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507606112 |
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