Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide

Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse. Here, we describe a peptide that selectively targets MRC1-expressing TAMs (MEMs). We performed in vivo peptid...

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Udgivet i:Sci Rep
Main Authors: Scodeller, Pablo, Simón-Gracia, Lorena, Kopanchuk, Sergei, Tobi, Allan, Kilk, Kalle, Säälik, Pille, Kurm, Kaarel, Squadrito, Mario Leonardo, Kotamraju, Venkata Ramana, Rinken, Ago, De Palma, Michele, Ruoslahti, Erkki, Teesalu, Tambet
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676682/
https://ncbi.nlm.nih.gov/pubmed/29116108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14709-x
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