Usefulness for the combination of G protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance

BACKGROUND: µ-Opioid receptor internalization is considered to be critically linked to antinociceptive tolerance. Although µ-opioid receptor agonists have been administered simultaneously with other drugs to control pain, little information is available regarding opioid–opioid interactions. Therefor...

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Publicat a:Mol Pain
Autors principals: Mori, Tomohisa, Kuzumaki, Naoko, Arima, Takamichi, Narita, Michiko, Tateishi, Ryunosuke, Kondo, Takashige, Hamada, Yusuke, Kuwata, Hirotsugu, Kawata, Miho, Yamazaki, Mitsuaki, Sugita, Kazuyuki, Matsuzawa, Akinobu, Baba, Kanae, Yamauchi, Takayasu, Higashiyama, Kimio, Nonaka, Miki, Miyano, Kanako, Uezono, Yasuhito, Narita, Minoru
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676499/
https://ncbi.nlm.nih.gov/pubmed/29056067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806917740030
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